近日，在举办的2017年美国肾脏病学会肾脏周上，来自葡萄牙的研究人员表示，咖啡因的摄入或会延长慢性肾脏疾病（CKD）患者的寿命。在一般人群中咖啡因的摄入与机体长寿直接相关，为了观察是否这种效应也存在于肾脏疾病患者中，研究人员通过对2328名CKD患者进行了一项队列前瞻性研究来观察摄入咖啡因和参与者死亡率的关系，这些参与者在1999年至2010年间参与了国家的连续健康与营养状况调查。

图片来源：medicalxpress.com

研究者发现，咖啡因和全因死亡率之间或许存在一种剂量依赖的负相关关系，相比最低四分位数咖啡因摄入水平的人群而言，第二、第三和最高四分位数咖啡因摄入水平的个体的死亡风险分别会降低12%、22%和24%。

研究者Bigotte Vieira博士表示，我们的研究阐明了慢性肾脏疾病患者中咖啡因摄入和死亡率之间的一种剂量依赖性的保护效应，这种关系并不依赖于潜在的多种因素，包括年龄、性别、种族、每年的家庭收入、教育水平、大概的肾小球滤过率（GFR）、肌酐比值、高血压、吸烟状况、血脂异常、体重指数、此前的心血管事件和饮食（酒精摄入、碳水化合物、多不饱和脂肪酸和纤维）。

最后研究者说道，本文研究结果表明，建议慢性肾脏疾病患者多摄入咖啡因或能有效降低其死亡率，这或许阐明了一种简单、临床有益的选择方式，尽管研究人员认为这种结果最好是在随机临床试验中进行证实，他们认为，观察性的研究并不能说明，咖啡因能够降低慢性肾脏疾病患者的死亡风险，但这只是暗示了诸如这种保护效应的可能性。（生物谷Bioon.com）

原始出处：

Caffeine consumption may help kidney disease patients live longer

Caffeine consumption may prolong the lives in patients with chronic kidney disease (CKD), according to a study that will be presented at ASN Kidney Week 2017 October 31-November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

Coffee consumption has been linked to a longer life in the general population. To see if this holds true for individuals with CKD, Miguel Bigotte Vieira, MD (Centro Hospitalar Lisboa Norte, in Portugal), and his colleagues examined the association of caffeine consumption with mortality among 2328 patients with CKD in a prospective US cohort, using the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2010.

The team found a dose-dependent inverse association between caffeine and all-cause mortality. Compared with those in the lowest quartile of caffeine consumption, those in the second, third, and highest quartiles had 12%, 22%, and 24% lower risks of dying.

"Our study showed a dose-dependent protective effect of caffeine consumption on mortality among patients with CKD. This association was independent of potential confounders including age, gender, race, annual family income, education level, estimated GFR, albumin/creatinine ratio, hypertension, smoking status, dyslipidemia, body mass index, previous cardiovascular events and diet: consumption of alcohol, carbohydrates, polyunsaturated fatty acids, and fibers," said Dr. Bigotte Vieira......